What question did this study set out to answer?

Investigate how T cell responses to vaccines differ in young versus older adults, focusing on durability and functionality.

November 25, 2025The Journal of ImmunologyOpen Access

CD4 Th17 T cells support vaccine durability despite age-related CD8 T cell dysfunction 2408

View Full Paper

Ask AI

Bookmark

Authors

VZV vaccination demonstrates CD4 and Th17 T cells influence immunity in aging, suggesting new vaccination strategies.

Investigate how T cell responses to vaccines differ in young versus older adults, focusing on durability and functionality.
Compared long-lived antigen-specific memory T cells in young and older adults after varicella zoster virus vaccination.
Stimulated PBMCs years post-vaccination to analyze VZV-reactive T cells.
Utilized spectral flow cytometry and single-cell sequencing for T cell characterization.
CD4 T cells maintained resilience to aging, while CD8 T cell diversity decreased with age.
Older adults showed altered CD8 T cell profiles with increased markers of end-differentiation.
Th17 T cells were identified as pro-inflammatory in the context of less effective vaccine responses.

Sturmlechner et al. (2025) studied this question.

View Full Paper

Ask AI

Bookmark