What question did this study set out to answer?

This study aims to characterize the CMV-specific memory T cell population over time in individuals with latent Cytomegalovirus.

November 25, 2025The Journal of ImmunologyOpen Access

HCMV-specific memory T cell clonotypes are phenotypically and functionally heterogeneous but stable over many years of latent infection 9373

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This study aims to characterize the CMV-specific memory T cell population over time in individuals with latent Cytomegalovirus.
Analyzed blood samples from multiple donors over 5-12 years
Utilized scRNAseq for T cell clonotype identification
Employed Functionally-Enriched TCR Sequencing to assess clone functionality
Identified expanded and stable CMV-specific memory T cell clonotypes
Found transcriptional and functional heterogeneity among clonotypes
Demonstrated stability of clone dominance and phenotype over 12 years

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Implication

Research finds significant stability in memory T cell clonotypes over years in individuals with latent Cytomegalovirus infection, implicating T cell exhaustion.

Cite This Study

Klebanoff et al. (2025) studied this question.

synapsesocial.com/papers/692502be87af00ed34ac2404 https://doi.org/10.1093/jimmun/vkaf283.2783

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Implication

Research finds significant stability in memory T cell clonotypes over years in individuals with latent Cytomegalovirus infection, implicating T cell exhaustion.

HCMV-specific memory T cell clonotypes are phenotypically and functionally heterogeneous but stable over many years of latent infection 9373

Key Points

Discussion

Implication

Cite This Study

HCMV-specific memory T cell clonotypes are phenotypically and functionally heterogeneous but stable over many years of latent infection 9373

Key Points

Discussion

Implication

Cite This Study

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