Key result
Latent CMV infection is linked to immune remodeling via clonal expansion of CMV-specific T cells.
Why the study?
CMV establishes lifelong latency and increases with age, but CMV-associated immune remodeling had not been systematically delineated at single-cell resolution.
Observational
Yes
Latent CMV infection drives significant and stable remodeling of the immune system, notably expanding GZMK+ CD8+ T cells, Th1 cells, and atypical B cells, which can be accurately predicted from single-cell RNA sequencing data.
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CMV-driven immune remodeling is hypothesis-generating; leaves open links to immunosenescence and clinical outcomes in older adults.
Grabauskas et al. (2026) conducted an observational in Cytomegalovirus (CMV) latency. Cytomegalovirus (CMV) latency was evaluated on Cellular and clonal signatures of latent CMV. Latent CMV infection was associated with immune remodeling, including clonal expansion of CMV-specific T cells enriched in GZMK⁺ CD8⁺ T cells and Th1 cells across multiple human cohorts.
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