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November 18, 2025Journal Of Clinical Periodontology

Efficacy of Periodontal Surgery With Adjunctive Systemic Antimicrobials in Patients Harbouring Porphyromonas gingivalis : A 48‐Month Randomised Clinical Trial

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Authors

AAAna Carrillo de AlbornozEMEduardo MonteroFPFinn Niclas Pickert

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Overview

Randomised clinical trial shows similar clinical outcomes in patients with periodontitis and adjunctive systemic antimicrobials, indicating stable results over time.

Key Points

  • Clinical outcomes improved and remained stable after surgical treatment with adjunctive antimicrobial therapy.
  • At 48 months, clinical endpoint differences were not statistically significant across treatment groups.
  • Randomised clinical trial involved patients with periodontitis stage III and IV positive for Porphyromonas gingivalis.
  • Neither treatment suppressed Porphyromonas gingivalis below detection limit after 48 months.

Cite This Study

Albornoz et al. (2025) studied this question.

synapsesocial.com/papers/692509ddc0ce034ddc3520e5https://doi.org/10.1111/jcpe.70060
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comparative Study of Systemic vs. Local Antibiotics with Subgingival Instrumentation in Stage III–IV Periodontitis: A Retrospective Analysis2024 · 10 citations
  2. 2Adjunctive Systemic Antimicrobials in the Treatment of Generalized Stage III, Grade C Periodontitis: A Triple-Blind, Randomized Placebo-Controlled Trial2026
  3. 3The Effects Of Amoxicillin And Metronidazole On Patients With Untreated Stage Iii Grade C Generalized Periodonti-tis: A Prospective Randomized Clinical Trial With 6- And 12-month Follow-ups2025
  4. 4Impact of Antibiotics on the Subgingival Microbiome in Advanced Periodontitis: Secondary Analysis of a Randomized Controlled Trial2025
  5. 5The Effect of Adjunctive Systemic Antibiotics on the Outcomes of Non‐Surgical Periodontal Therapy: A Retrospective Cohort Study2026 · 1 citations