What question did this study set out to answer?

This study aims to evaluate the effectiveness of systemic antibiotics alongside subgingival instrumentation in treating severe periodontitis.

Adjunctive Systemic Antimicrobials in the Treatment of Generalized Stage III, Grade C Periodontitis: A Triple-Blind, Randomized Placebo-Controlled Trial

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Randomized trial evaluates antibiotic effects on periodontal health, showing no significant therapeutic advantage.

This study aims to evaluate the effectiveness of systemic antibiotics alongside subgingival instrumentation in treating severe periodontitis.
Triple-blind, randomized controlled trial
50 young adults received either subgingival instrumentation with amoxicillin/metronidazole or placebo
Periodontal parameters were measured at baseline, 6 months, and 12 months
Both groups showed significant clinical improvements at 12 months (p < 0.001)
Test group showed greater mean reduction in probing pocket depth (0.53 mm, p = 0.024) and greater clinical attachment level gain (0.61 mm, p < 0.001)
No significant differences in therapeutic success rates (96% test vs. 88% control, p = 0.609)

Stenchláková et al. (2026) studied this question.

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