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November 17, 2025Cerebrovascular Diseases ExtraOpen Access

Predictive Value of Cardiac Biomarkers Combined with Clinical, Radiological Factors for Venous Thromboembolism in Patients with Spontaneous Intracerebral Hemorrhage

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Authors

MYMeng-yuan YuanXFXiguang FuTCTong Chen

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Overview

Retrospective analysis predicts venous thromboembolism risk in spontaneous intracerebral hemorrhage patients, suggesting improved prophylaxis strategies.

Key Points

  • This research aims to develop a predictive model for venous thromboembolism risk in patients with spontaneous intracerebral hemorrhage using cardiac biomarkers and clinical factors.
  • Retrospective enrollment of ICH patients from October 2019 to December 2022.
  • Collected baseline clinical characteristics, laboratory data, and radiological features.
  • Classified patients into VTE group based on pulmonary embolism and deep vein thrombosis.
  • Used Cox regression analysis to identify independent predictors of in-hospital VTE.
  • Developed a nomogram and evaluated its performance using concordance index and decision curve analysis.
  • 170 ICH patients were analyzed with 36 (21.2%) classified in the VTE group.
  • Identified independent predictors: age, baseline edema volume, IVH, Myo, and BNP.
  • Compared to clinical-radiological model, combined model showed better predictive performance (C-index: 0.791 vs 0.749).
  • The developed nomogram demonstrated good calibration and clinical utility across risk thresholds.

Cite This Study

Yuan et al. (2025) studied this question.

synapsesocial.com/papers/692509fbc0ce034ddc3530e2https://doi.org/10.1159/000549487
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Development of an Efficient Nomogram for Prediction of Early Deep Vein Thrombosis Following Intracerebral Hemorrhage2024
  2. 2Development and Validation of a Prediction Model for Venous Thromboembolic Events Following Hematoma Evacuation in Patients with Spontaneous Intracerebral Hemorrhage2025
  3. 3Risk factors for intracranial haemorrhage in patients with pulmonary embolism treated with thrombolytic therapy Development of the PE-CH Score2016 · 59 citations
  4. 4Venous Thromboembolism in ICU Patients with Intracerebral Hemorrhage: Risk Factors and the Prognosis After Anticoagulation Therapy2021 · 17 citations
  5. 5Atrial fibrillation as an independent risk factor for venous thromboembolism in intracerebral hemorrhage patients: a multicenter retrospective cohort study2026