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November 15, 2025Genes and ImmunityOpen Access

Spatiotemporal transcriptomic insights into ferroptosis and TFRC-linked immune interactions in ischemia-reperfusion acute kidney injury

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Authors

YWYulin WangCZCheng ZhuSLShiqi Lv

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Overview

This study reveals ferroptosis and gene expression links to immune activation in acute kidney injury, suggesting potential therapeutic targets.

Key Points

  • The study investigates the role of ferroptosis-related gene expression and immune interactions in acute kidney injury.
  • Analyzed gene expression changes in a mouse model of ischemia-reperfusion-induced AKI.
  • Constructed a machine learning-based diagnostic model.
  • Integrated single-cell and spatial transcriptomics to assess gene expression in proximity to immune cells.
  • Performed in vivo administration of a ferroptosis inhibitor to evaluate effects on macrophage infiltration and renal injury.
  • Executed in vitro co-culture experiments focusing on tubular cells and immune cell activation.
  • Identified five ferroptosis-related genes associated with immune infiltration.
  • TFRC showed close spatial proximity to infiltrating macrophages.
  • Ferroptosis inhibitor NSC306711 significantly reduced macrophage infiltration and renal injury.
  • Co-culture experiments indicated TfR1 degradation alleviated hypoxia-induced damage.
  • The findings underscore the interaction between ferroptosis and immune mechanisms in AKI.

Cite This Study

Wang et al. (2025) studied this question.

synapsesocial.com/papers/69251994c0ce034ddc353686https://doi.org/10.1038/s41435-025-00364-0
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Crosstalk among proximal tubular cells, macrophages, and fibroblasts in acute kidney injury: single-cell profiling from the perspective of ferroptosis2024 · 12 citations
  2. 2Molecular mechanisms of ferroptosis in renal ischemia-reperfusion injury Investigated via bioinformatics analysis and animal experiments2024
  3. 3Ferroptosis in Chronic Kidney Disease: Molecular Mechanisms andTherapeutic Targets2026
  4. 4Discovery of ferroptosis-related genes in renal ischemia reperfusion and evaluate the potential impact on kidney transplantation2024 · 4 citations
  5. 5Dynamic Regulation of Ferroptosis in a Neonatal Rat Model of Postnatal Hypoxia-Induced Acute Kidney Injury2026