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May 7, 2026AntioxidantsOpen Access

Dynamic Regulation of Ferroptosis in a Neonatal Rat Model of Postnatal Hypoxia-Induced Acute Kidney Injury

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Authors

TLTzu-Hao LiuZuoying Armed Forces General HospitalBCBo-Hau ChenTaoyuan Armed Forces General HospitalGLGuan-Hong LinKaohsiung Veterans General Hospital

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Implication

Randomized trial investigates the role of ferroptosis in acute kidney injury from hypoxia in neonates, suggesting a new treatment approach.

Key Points

  • This study aims to investigate the role of ferroptosis in hypoxia-induced acute kidney injury in neonates.
  • Utilized a neonatal rat model to induce hypoxia and assess renal injury.
  • Analyzed changes in iron homeostasis and lipid peroxidation related to hypoxia exposure.
  • Evaluated structural and functional renal outcomes after reoxygenation.
  • Hypoxia led to significant iron accumulation and increased lipid peroxidation in renal tissues.
  • Reoxygenation improved renal structure and function but did not fully reverse fibrotic changes.
  • Ferroptosis pathways were linked to the progression of hypoxia-induced renal injury.

Cite This Study

Liu et al. (2026) studied this question.

synapsesocial.com/papers/69fc2c1f8b49bacb8b347c8dhttps://doi.org/10.3390/antiox15050582
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Klotho/FGF23 Axis in Chronic Kidney Disease and Cardiovascular Disease2016 · 223 citations
  2. 2Neonatal Hypoxic–Ischemic Encephalopathy: Perspectives of Neuroprotective and Neuroregenerative Treatments2022 · 31 citations
  3. 3Efficacy of the combination of N-acetylcysteine and desferrioxamine in the prevention and treatment of gentamicin-induced acute renal failure in male Wistar rats2009 · 34 citations
  4. 4Hypoxia-Induced Kidney Injury in Newborn Rats2023 · 4 citations
  5. 5Iron Chelation as a Potential Therapeutic Strategy for AKI Prevention2019 · 59 citations