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November 14, 2025Acta medica LituanicaOpen Access

Heavy Chain Disease with Cystic Lung Disease Presenting as Recurrent Spontaneous Pneumothorax in a Young Adult

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Authors

KDKonstantinos DodosTKTsampika-Vasileia KalamaraVGVasiliki Epameinondas Georgakopoulou

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Overview

Case reports recurrent pneumothoraces in a 23-year-old with cystic lung disease, suggesting γ-heavy chain disease as a rare cause.

Key Points

  • This report aims to highlight γ-heavy chain disease as a potential cause of cystic lung disease and recurrent spontaneous pneumothorax.
  • Patient evaluation included high-resolution computed tomography and laboratory tests for monoclonal spike.
  • Immunofixation was conducted to confirm the presence of IgG heavy chain without light chains.
  • Bone marrow biopsy was performed to assess plasma cell levels and exclude malignancy.
  • The patient presented with recurrent spontaneous pneumothorax due to cystic lung disease.
  • Laboratory results showed a discrete monoclonal spike indicating γ-heavy chain disease.
  • Alternative causes for cystic lung disease were excluded, highlighting the uniqueness of this condition.

Cite This Study

Dodos et al. (2025) studied this question.

synapsesocial.com/papers/69251999c0ce034ddc353a75https://doi.org/10.15388/amed.2025.32.2.15
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1An Uncommon Cause of Cystic Lung Disease2026
  2. 2Novel Laboratory Approaches in Heavy Chain Disease With Discordant Immunoglobulin Quantitation: A Case Report and Literature Review2026
  3. 3Not So Crystal Clear: Pulmonary Crystal-Storing Histiocytosis Without Haematological Disease: A Unique Radiological Manifestation and Review of the Literature2026
  4. 4C80-05 Beyond the Obvious: Pulmonary Light Chain Deposition Disease Presenting as Multiple Lung Nodules2026
  5. 5Birt–Hogg–Dubé syndrome: a hidden genetic cause of recurrent pneumothorax in a non-smoker2026