Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 14, 2025Blood Cancer DiscoveryOpen Access

Composition and functional state of T and NK cells in the extramedullary myeloma tumor microenvironment

View Full Paper
Ask AI
Bookmark
Share

Authors

ASAnjana Anilkumar SitharaVKVeronika KapustováDZDavid Zihala

Discussion

Loading...

Member takes

Overview

Single-cell RNA sequencing reveals T and NK cell dysfunction in extramedullary myeloma, indicating immune checkpoint involvement.

Key Points

  • This research aims to understand the immune cell composition and functionality in the extramedullary myeloma tumor microenvironment.
  • Analyzed immune cell composition using single-cell RNA sequencing and flow cytometry.
  • Compared extramedullary myeloma tumor microenvironment with multiple myeloma bone marrow.
  • Studied the expression of immune checkpoints in T and NK cells.
  • Identified distinct differences in immune cell composition between extramedullary and bone marrow environments.
  • Found reduced effector-to-tumor cell ratio and lower CD4⁺ T cell counts in extramedullary tumors.
  • Observed a high proportion of exhausted CD8+ T cells, indicating immune dysfunction.

Cite This Study

Sithara et al. (2025) studied this question.

synapsesocial.com/papers/692519a7c0ce034ddc353e8ahttps://doi.org/10.1158/2643-3230.bcd-25-0170
View Full Paper
Ask AI
Bookmark
Share