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November 1, 2025The Journal of ImmunologyOpen Access

NK cell dysregulation in the multiple myeloma: insights from multi-modal profiling of the bone marrow microenvironment 2812

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Authors

SCSiobhán B. CashmanAAAruna AyerTSTeresa Swift

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Overview

Observations show altered NK cells in the tumor microenvironment of multiple myeloma, suggesting immune system impacts on this hematological malignancy.

Key Points

  • The aim is to understand NK cell dynamics in the tumor microenvironment of multiple myeloma.
  • Analyzed bone marrow samples from healthy and newly diagnosed multiple myeloma cohorts.
  • Utilized flow cytometry, spectral flow cytometry, and single-cell RNA sequencing with CITE-seq.
  • Characterized NK cell subsets and their expression patterns.
  • Total NK cells increased while the CD56DimCD16+ NK cell subset decreased in multiple myeloma.
  • CD56DimCD16+ NK cells exhibited a more mature phenotype in multiple myeloma patients.
  • CD57+ NK cells were enriched in multiple myeloma with increased KIR-expressing cells and granzyme transcripts.

Cite This Study

Cashman et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc35981fhttps://doi.org/10.1093/jimmun/vkaf283.693
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Mapping the cytotoxic landscape: an integrated analysis of T cell heterogeneity in the bone marrow microenvironment of multiple myeloma 28102025
  2. 2NK cells with adhesion defects and reduced cytotoxic functions are associated with a poor prognosis in Multiple Myeloma.2024 · 21 citations
  3. 3Composition and functional state of T and NK cells in the extramedullary myeloma tumor microenvironment2025
  4. 4Composition and Functional State of T and NK Cells in the Extramedullary Myeloma Tumor Microenvironment2025 · 5 citations
  5. 5Coevolution of NK and Tumor Cell States Along Multiple Myeloma Progression from Precursor Conditions2026