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July 29, 2026Current Issues in Molecular BiologyOpen Access

Association Between Natural Killer Cell Subsets (CD56bright and CD56dim) and Infectious Complications in Newly Diagnosed Multiple Myeloma (NDMM) Patients

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Authors

AKAshraf KakooSalahaddin University-ErbilMFMohammad H. ForouzanfarAga Khan UniversityAYAhmed YassinHawler Medical University

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Overview

Randomized trial reveals significant association of NK cell subsets with infections in NDMM patients, suggesting impacts on patient monitoring.

Key Points

  • This study aims to assess the relationship between NK cell subsets and infections in newly diagnosed multiple myeloma patients.
  • Peripheral blood samples collected from 47 NDMM patients.
  • NK cell immunophenotype analysis performed using flow cytometry.
  • Infection screening based on clinical symptoms and pathogens.
  • NDMM patients showed a significant increase in circulating NK cells (p = 0.001) compared to healthy controls.
  • Infectious complications were seen in 31% of NDMM patients, with 19.1% viral and 12.7% bacterial infections.
  • A shift was noted in NK cell subsets, with CD56bright expanding (p = 0.01) and CD56dim reducing (p = 0.01).

Cite This Study

Kakoo et al. (2026) studied this question.

synapsesocial.com/papers/6a69a2aec8da07d9defa6649https://doi.org/10.3390/cimb48080761
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Also Consider

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  3. 3Immune biomarkers of increased infection risk in multiple myeloma2026 · 4 citations
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