What question did this study set out to answer?

Characterize immune profiles throughout multiple myeloma progression and identify biomarkers indicating increased infection risk.

December 8, 2025BloodOpen Access

Immune biomarkers of increased risk of infection in multiple myeloma (MM)

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Authors

AZAintzane ZabaletaClinica Universidad de Navarra MMMichaela MachuMasaryk University PBPanagiotis BakourosNational and Kapodistrian University of Athens

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Implication

Observational study identifies immune profiles associated with increased infection risk in multiple myeloma patients, suggesting new insights for management.

Key Points

Characterize immune profiles throughout multiple myeloma progression and identify biomarkers indicating increased infection risk.
Analyzed immune profiles in 2,150 multiple myeloma patients
Utilized bone marrow and peripheral blood samples
Employed logistic regression to identify immune biomarkers
Infection risk increased across multiple myeloma stages: 13% in MGUS to 54% in RRMM
Identified specific immune profiles linked to infection risk, including reductions in memory B cells
Developed an immune score predicting infection risk validated across multiple cohorts

Cite This Study

Zabaleta et al. (2025) studied this question.

synapsesocial.com/papers/69362f6e4fa91c937236e0d6 https://doi.org/10.1182/blood-2025-365

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Implication

Observational study identifies immune profiles associated with increased infection risk in multiple myeloma patients, suggesting new insights for management.

Immune biomarkers of increased risk of infection in multiple myeloma (MM)

Discussion

Member takes

Implication

Key Points

Cite This Study

Immune biomarkers of increased risk of infection in multiple myeloma (MM)

Discussion

Member takes

Implication

Key Points

Cite This Study

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