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December 8, 2025BloodOpen Access

Infection rates and mortality in multiple myeloma: Impact of blood counts and IgG levels over time

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Authors

NPNeha PuttaguntaPNPhyu Thin NaingKZKelvin Zheng

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Overview

Retrospective analysis shows lower absolute neutrophil count and IgG levels correlate with infection mortality in multiple myeloma patients.

Key Points

  • The study explores the association between blood counts, IgG levels, and infection-related mortality in multiple myeloma patients.
  • Retrospective review of 173 multiple myeloma patients diagnosed between 2021-2023 at Northwell Health.
  • Data collected included demographics, lab results, treatment history, and infection rates.
  • Key immunological parameters measured were ANC, ALC, and IgG levels at diagnosis, and follow-up at 3 and 6 months.
  • Infection was the leading cause of death, particularly due to COVID-19 in this cohort.
  • Patients who died from infection had lower median ANC at diagnosis and follow-up, while ALC did not predict mortality.
  • A trend toward lower baseline IgG levels was observed in infection-related deaths, indicating potential risk factors.

Cite This Study

Puttagunta et al. (2025) studied this question.

synapsesocial.com/papers/69362f714fa91c937236e1d3https://doi.org/10.1182/blood-2025-7512
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Trends in infection-related mortality among older adults with multiple myeloma in the United States over the last two decades.2026
  2. 2Immune biomarkers of increased risk of infection in multiple myeloma (MM)2025
  3. 3Incidence and risk factors for infections in the real-world setting in newly diagnosed myeloma patients treated with modern induction regimens2025
  4. 4Hematologic predictors of serious infection and impact of serious infection on long-term mortality in AML patients: Insights from propensity-matched real-world cohorts2025
  5. 5Trends and disparities in infection-related mortality among non-Hodgkin lymphoma patients in the United States, 1999–20232025