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December 8, 2025BloodOpen Access

Incidence and risk factors for infections in the real-world setting in newly diagnosed myeloma patients treated with modern induction regimens

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Authors

EKEfstathios KastritisESEirini SoliaINIoannis Ntanasis‐Stathopoulos

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Overview

Observational study finds high infection rates in newly diagnosed myeloma patients, suggesting renal dysfunction and performance status are key risk factors.

Key Points

  • To evaluate the incidence and risk factors for infections in newly diagnosed myeloma patients receiving modern treatment regimens.
  • Analyzed a cohort of 541 newly diagnosed myeloma patients treated after 2020.
  • Recorded grade ≥2 infections prospectively over 12 months post-treatment.
  • Calculated time-to-infection from treatment initiation.
  • 31% of patients experienced at least one grade ≥2 infection within 12 months.
  • Common infections included respiratory tract infections and COVID-19.
  • Renal dysfunction and poor performance status were significant predictors of higher-grade infections.

Cite This Study

Kastritis et al. (2025) studied this question.

synapsesocial.com/papers/69362f4b4fa91c937236d7dbhttps://doi.org/10.1182/blood-2025-2228
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Immune biomarkers of increased risk of infection in multiple myeloma (MM)2025
  2. 2Risk of infections in multiple myeloma. A populationbased study on 8,672 multiple myeloma patients diagnosed 2008-2021 from the Swedish Myeloma Registry2024 · 13 citations
  3. 3Incidence of infections in clinical trials of treatments for relapsed/refractory multiple myeloma: Systematic review and meta-analysis.2024
  4. 4Infection rates and mortality in multiple myeloma: Impact of blood counts and IgG levels over time2025
  5. 5Assessment of bacterial infection risk factors and related complications in newly diagnosed multiple myeloma: A retrospective cohort analysis2026