What question did this study set out to answer?

To identify independent risk factors for nosocomial infection in multiple myeloma and construct and validate a predictive nomogram to guide targeted infection prevention.

August 16, 2026Annals of HematologyOpen Access

Development and multicenter validation of a predictive nomogram for infection risk in patients with multiple myeloma

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Authors

SCSiliang ChenChang'an University ZCZhilin ChenFirst Affiliated Hospital of Guangzhou University of Chinese Medicine HCHao ChenXiamen University

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Implication

Retrospective cohort study demonstrates high accuracy of a multivariable nomogram for predicting infection in multiple myeloma, indicating potential for individualized prevention.

Key Points

To identify independent risk factors for nosocomial infection in multiple myeloma and construct and validate a predictive nomogram to guide targeted infection prevention.
Retrospectively analyzed 245 patients with multiple myeloma admitted between 2005 and 2024 at a single center, alongside an external validation cohort.
Evaluated clinical stages, treatment regimens, microbiological cultures, and laboratory biomarkers using univariate and multivariate logistic regression.
ISS stage III, lower hemoglobin, lower albumin, lower plateletcrit, elevated C-reactive protein, higher M-protein, and higher uric acid were independent predictors of infection (all P < 0.05).
The integrated prediction model demonstrated high discriminatory ability with an internal AUC of 0.988 and maintained strong performance in an external validation cohort with an AUC of 0.839.

Cite This Study

Chen et al. (2026) studied this question.

synapsesocial.com/papers/6a817a21f2fb91fc834adc28 https://doi.org/10.1007/s00277-026-07228-1

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Implication

Retrospective cohort study demonstrates high accuracy of a multivariable nomogram for predicting infection in multiple myeloma, indicating potential for individualized prevention.

Development and multicenter validation of a predictive nomogram for infection risk in patients with multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

Development and multicenter validation of a predictive nomogram for infection risk in patients with multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

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