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May 24, 2026International Journal of Molecular SciencesOpen Access

Coevolution of NK and Tumor Cell States Along Multiple Myeloma Progression from Precursor Conditions

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Authors

CAC. AquilinaUniversity of PalermoARAndrea RomanoUniversity of CataniaACAnna Maria CorsaleAOL (United States)

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Overview

Randomized trial investigates NK cell states and tumor adaptation in multiple myeloma, implying complex interactions.

Key Points

  • This research aims to understand the changes in natural killer (NK) cell states during multiple myeloma progression and their interaction with plasma cells.
  • Integrated NK cell functional states with plasma cell susceptibility programs from CRISPR screens.
  • Utilized public single-cell RNA sequencing datasets to analyze NK cell heterogeneity and dynamics.
  • Validated findings through multiparametric flow cytometry.
  • Identified stage-specific changes in NK cell states with early expansion of CD56dim cells followed by contraction.
  • Detected increased KLRC1 expression in CD56bright cells, indicating immune adaptation.
  • Noted selective expression of HLA-E in CD16+ monocytes, contributing to NK cell regulation across disease stages.

Cite This Study

Aquilina et al. (2026) studied this question.

synapsesocial.com/papers/6a1296d548a0ea1665673eefhttps://doi.org/10.3390/ijms27114682
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Natural killer cells affect the natural course, drug resistance, and prognosis of multiple myeloma2024 · 9 citations
  2. 2NK cell dysregulation in the multiple myeloma: insights from multi-modal profiling of the bone marrow microenvironment 28122025
  3. 3NK cells with adhesion defects and reduced cytotoxic functions are associated with a poor prognosis in Multiple Myeloma.2024 · 21 citations
  4. 4Exploring natural killer cell-related biomarkers in multiple myeloma: a novel nature killer cell-related model predicting prognosis and immunotherapy response using single-cell study2024 · 7 citations
  5. 5Composition and functional state of T and NK cells in the extramedullary myeloma tumor microenvironment2025