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November 13, 2025Frontiers in Aging NeuroscienceOpen Access

Glymphatic system impairment in cerebral small vessel disease: associations with perivascular space volume and cognition

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Authors

LALulu AiZLZhiwei LiHHHuipeng Huang

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Overview

Analysis reveals glymphatic dysfunction affects cognition in cerebral small vessel disease via perivascular space.

Key Points

  • To investigate the relationships among glymphatic function, perivascular space, and cognitive performance in cerebral small vessel disease (CSVD).
  • Enrolled 120 CSVD patients and 40 healthy controls.
  • Assessed glymphatic function using the left ALPS index from diffusion tensor imaging analysis.
  • Analyzed group comparisons in the ALPS index and PVS volume fraction, and correlations among glymphatic function, PVS burden, and cognition.
  • CSVD patients had decreased ALPS index and increased PVS volume fraction in basal ganglia, caudate, putamen, and hippocampus.
  • ALPS index inversely correlated with PVS volume fraction in basal ganglia and thalamus.
  • Lower ALPS index was associated with poorer global cognition, executive function, processing speed, and visuospatial function.

Cite This Study

Ai et al. (2025) studied this question.

synapsesocial.com/papers/692523bbc0ce034ddc354a05https://doi.org/10.3389/fnagi.2025.1680094
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Relationship of glymphatic markers, neurotransmitters with cognitive performance in cerebral small vessel disease: A novel investigation2025
  2. 2Association between MRI indicators of the glymphatic system and cognition in high-risk populations for Alzheimer's disease2026 · 2 citations
  3. 3The Relationship between Glymphatic Dysfunction and Post-stroke Cognitive Impairment2025 · 2 citations
  4. 4MRI Evaluation of Glymphatic Dysfunction in Cerebral Small Vessel Disease: Hypertensive vs. Normotensive Patients2025
  5. 5The relationship between amyloid pathology, cerebral small vessel disease, glymphatic dysfunction, and cognition: a study based on Alzheimer’s disease continuum participants2024 · 126 citations