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November 1, 2025European Journal of NeuroscienceOpen Access

MRI Evaluation of Glymphatic Dysfunction in Cerebral Small Vessel Disease: Hypertensive vs. Normotensive Patients

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Authors

MHMingming HuangXLXinyue LyuYXYong Xia

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Overview

Retrospective analysis reveals hypertension impacts glymphatic dysfunction in CSVD patients, suggesting blood pressure management is crucial.

Key Points

  • This research examines the effect of hypertension on the glymphatic system in patients with cerebral small vessel disease.
  • Retrospective analysis of 72 CSVD patients (37 hypertensive and 35 normotensive)
  • MRI-derived glymphatic system metrics analyzed
  • Comparative evaluation against 40 age-matched healthy controls.
  • Hypertensive CSVD patients exhibited lower ALPS index compared to normotensive counterparts
  • Higher free water in white matter and increased choroid plexus volume were observed in hypertensive patients
  • Systolic blood pressure negatively correlated with ALPS index and positively with free water and choroid plexus volume.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/69254366c0ce034ddc358491https://doi.org/10.1111/ejn.70305
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Glymphatic system impairment in cerebral small vessel disease: associations with perivascular space volume and cognition2025
  2. 2A preliminary study of MRI-Derived Glymphatic System indices in early normal elderly people2025
  3. 3Disruptions of deep medullary veins and MRI indices of glymphatic function in cerebral small vessel disease2025 · 2 citations
  4. 4Relationship of glymphatic markers, neurotransmitters with cognitive performance in cerebral small vessel disease: A novel investigation2025
  5. 5Magnetic resonance imaging assessment of cerebral small vessel disease intensification in patients with severe aortic valve stenosis2021 · 1 citations