What type of study is this?

This is a Human Clinical Trial study (also classified as: RCT).

What question did this study set out to answer?

The research aims to evaluate the effectiveness of liposomal bupivacaine for pain control in thoracoscopic surgery.

November 11, 2025International Journal of SurgeryOpen Access

Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung resection: a multicenter, randomized, double-blind, clinical trial

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Authors

XSXi-Sheng Shan DLDa Wei Liao JGJian Guo

Discussion

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Implication

Randomized controlled trial shows lower pain scores and opioid consumption in lung surgery patients receiving liposomal bupivacaine, indicating improved postoperative analgesia.

Key Points

The research aims to evaluate the effectiveness of liposomal bupivacaine for pain control in thoracoscopic surgery.
Multicenter, randomized controlled trial design
272 adults assigned to liposomal bupivacaine or bupivacaine hydrochloride
Preoperative ultrasound-guided erector spinae plane block
Primary outcome measured was cumulative numeric rating scale pain score at rest
Secondary outcomes included 72-hour pain, opioid consumption, and recovery quality.
Liposomal bupivacaine group reported significantly lower 72-hour cumulative rest pain
Pain score difference: 205.0 vs 232.5, P < 0.001
Pain relief at 24 and 32 hours achieved clinically important difference
Lower opioid consumption observed in the liposomal group
Recovery quality was higher in patients receiving liposomal bupivacaine.

Cite This Study

Shan et al. (2025) studied this question.

synapsesocial.com/papers/69252e9ec0ce034ddc356528 https://doi.org/10.1097/js9.0000000000003956

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Implication

Randomized controlled trial shows lower pain scores and opioid consumption in lung surgery patients receiving liposomal bupivacaine, indicating improved postoperative analgesia.

Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung resection: a multicenter, randomized, double-blind, clinical trial

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung resection: a multicenter, randomized, double-blind, clinical trial

Discussion

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Implication

Key Points

Cite This Study

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