What question did this study set out to answer?

To assess the efficacy of liposomal bupivacaine versus bupivacaine hydrochloride for preoperative erector spinae plane block on pain control after video-assisted thoracoscopic lung resection.

November 11, 2025International Journal of SurgeryOpen Access

Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung resection: a multicenter, randomized, double-blind, clinical trial

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Authors

XSXi-sheng ShanSoochow University DLDawei LiaoSinopec (China)JGJian GuoShenzhen Academy of Robotics

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Implication

Randomized double-blind trial shows liposomal bupivacaine nerve block reduces 72-hour rest pain after thoracoscopic lung resection, indicating modest clinical benefit over standard bupivacaine.

Key Points

To assess the efficacy of liposomal bupivacaine versus bupivacaine hydrochloride for preoperative erector spinae plane block on pain control after video-assisted thoracoscopic lung resection.
Multicenter, randomized, double-blind clinical trial enrolling 272 adults randomized 1:1 to receive preoperative ultrasound-guided ESPB with either liposomal bupivacaine or bupivacaine hydrochloride.
Evaluated a primary outcome of cumulative numeric rating scale pain score at rest (area under the curve from 0 to 72 hours postoperatively) in 267 analyzed patients.
The 72-hour cumulative rest pain score was significantly lower with liposomal bupivacaine than bupivacaine hydrochloride (205.0 vs 232.5; difference, -26.5; 95% CI, -35.5 to -17.5; P < 0.001), but did not reach the minimal clinically important difference of 72 (predefined) or 42 (anchor-based).
Rest and activity pain scores at 24 and 32 hours achieved the clinically important difference of 1, accompanied by significantly lower 72-hour opioid consumption and improved recovery quality.

Cite This Study

Shan et al. (2025) studied this question.

synapsesocial.com/papers/6ab31caee0a077f45ceb0c42 https://doi.org/10.1097/js9.0000000000003956

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Implication

Randomized double-blind trial shows liposomal bupivacaine nerve block reduces 72-hour rest pain after thoracoscopic lung resection, indicating modest clinical benefit over standard bupivacaine.

Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung resection: a multicenter, randomized, double-blind, clinical trial

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Cite This Study

Effect of liposomal bupivacaine for preoperative erector spinae plane block on postoperative pain following video-assisted thoracoscopic lung resection: a multicenter, randomized, double-blind, clinical trial

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