Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
November 10, 2025International Journal of Molecular SciencesOpen Access

IGF Pathway Components as Potential Biomarkers in Gastric Cancer

View Full Paper
Ask AI
Bookmark
Share

Authors

BCBetül CeylanerFŞFurkan ŞahinAYAnil Yildiz

Discussion

Loading...

Member takes

Overview

This research highlights the diagnostic potential of IGF-1, IGFBP-4, and IGFBP-5 in gastric cancer, indicating they may improve prognosis.

Key Points

  • The aim is to explore IGF pathway components as potential biomarkers for early diagnosis of gastric cancer.
  • Measured protein levels in serum samples of 40 gastric cancer patients and 40 healthy controls using ELISA method.
  • Analyzed data to compare levels of IGF-1, IGFBP-4, IGFBP-5, and PAPP-A between groups.
  • Conducted ROC analyses to evaluate the diagnostic properties of biomarkers.
  • IGF-1 levels decreased significantly in gastric cancer patients.
  • IGFBP-4 levels increased significantly in gastric cancer patients.
  • IGFBP-5 levels were lower in gastric cancer patients.
  • PAPP-A levels did not differ significantly between groups.
  • ROC analyses indicated IGF-1, IGFBP-4, and IGFBP-5 have good discriminatory properties for diagnosis.

Cite This Study

Ceylaner et al. (2025) studied this question.

synapsesocial.com/papers/69253a24c0ce034ddc357202https://doi.org/10.3390/ijms262210880
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Comprehensive Analysis of IGFBPs as Biomarkers in Gastric Cancer2021 · 32 citations
  2. 2Serum and tissue IGFBP2 as a prognostic biomarker in gastric adenocarcinoma: A multi-cohort clinical validation study2026 · 1 citations
  3. 3Impact of Insulin-like Growth Factor System on the Progression and Survival of Gastric Adenocarcinoma2024
  4. 4Preoperative serum levels of insulin-like growth factor-binding protein 2 predict prognosis of gastric cancer patients2016 · 21 citations
  5. 5Identification of Serum Biomarkers to Monitor Therapeutic Response in Intestinal-Type Gastric Cancer2024 · 1 citations