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May 24, 2026Journal of the Formosan Medical AssociationOpen Access

Serum and tissue IGFBP2 as a prognostic biomarker in gastric adenocarcinoma: A multi-cohort clinical validation study

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Authors

KTKun‐Feng TsaiCSChia‐Tung ShunYFYu-Jen Fang

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Overview

Cohort study assesses IGFBP2's impact on gastric cancer prognosis, indicating its potential as a biomarker.

Key Points

  • The aim is to investigate the role of insulin-like growth factors, particularly IGFBP2, as prognostic biomarkers in gastric adenocarcinoma.
  • Cohort study with 397 patients diagnosed with gastric adenocarcinoma.
  • Serum levels of IGFBP2 measured and analyzed for correlation with overall survival.
  • Immunohistochemistry applied to assess IGF protein expression in tumor tissues.
  • Higher serum IGFBP2 levels correlated with worse overall survival (Cohort 1, p < 0.0001; Cohort 2, p < 0.00001).
  • Cox regression analysis demonstrated that IGFBP2 is a significant predictor of poor prognosis (HR: 1.90; p = 0.0011).
  • Comparison showed significantly higher IGFBP2 levels in gastric cancer patients than in the control gastritis group (p = 0.0001).

Cite This Study

Tsai et al. (2026) studied this question.

synapsesocial.com/papers/6a12958948a0ea16656719dahttps://doi.org/10.1016/j.jfma.2026.04.112
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Also Consider

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  1. 1Impact of Insulin-like Growth Factor System on the Progression and Survival of Gastric Adenocarcinoma2024
  2. 2Preoperative serum levels of insulin-like growth factor-binding protein 2 predict prognosis of gastric cancer patients2016 · 21 citations
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  5. 5Elevated serum insulin-like growth factor (IGF)-II and IGF binding protein-2 in patients with colorectal cancer2000 · 113 citations