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November 1, 2000British Journal of CancerOpen Access

Mean IGFBP-2 SDS were significantly elevated in patients with Dukes B (P<0.001), Dukes C (P<0.001) and advanced disease (P<0.0001) compared with controls, with a significant trend from early to advanced disease (P<0.001).

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Population

149 individuals, comprising 92 patients with colorectal cancer and 57 individuals who had a normal…

Design

Case-control

Authors

ARAndrew G. RenehanJJJim R. JonesCPChristopher S. Potten

Discussion

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Overview

IGFBP-2 elevation was associated with colorectal cancer stage; hypothesis-generating and leaves open any adjunctive surveillance role.

Structured PICO

P
Population
149 individuals, comprising 92 patients with colorectal cancer (cases: 12 Dukes A, 25 Dukes B, 13 Dukes C, 42 advanced disease) and 57 individuals who had a normal colonoscopy (controls).
O
Outcome
Relationships of serum IGF-I, IGF-II, IGFBP-2, and IGFBP-3 with key clinicopathological parameterssurrogate

Serum IGFBP-2 levels correlate with tumor load and disease stage in colorectal cancer, and in combination with CEA, may have an adjunct role in cancer surveillance.

Cite This Study

Renehan et al. (2000) studied this question.

synapsesocial.com/papers/6a7075868031ec7bb1dc5bfbhttps://doi.org/10.1054/bjoc.2000.1462
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Expression of the Insulin-like Growth Factor Binding Proteins (IGFBPs) in Colon Cancer2008
  2. 2Serum and tissue IGFBP2 as a prognostic biomarker in gastric adenocarcinoma: A multi-cohort clinical validation study2026 · 1 citations
  3. 3Impact of Insulin-like Growth Factor System on the Progression and Survival of Gastric Adenocarcinoma2024
  4. 4Preoperative serum levels of insulin-like growth factor-binding protein 2 predict prognosis of gastric cancer patients2016 · 21 citations
  5. 5Serum insulin-like growth factor-binding protein-2 (IGFBP-2) is increased and IGFBP-3 is decreased in patients with prostate cancer: correlation with serum prostate-specific antigen.1993 · 225 citations