Key result
Truncated abstract lacks quantitative results for IGFBP expression in colon cancer versus normal tissue.
Why the study?
Do tissue IGFBP-2, -3, and -4 levels differ between colon cancer tissue and adjacent normal tissue, and do they correlate with clinicopathologic characteristics?
Observational (n=102)
Do tissue IGFBP-2, -3, and -4 levels differ between colon cancer tissue and adjacent normal tissue, and do they correlate with clinicopathologic characteristics?
Answers are grounded in this paper and cite their sources.
Absence of quantitative results limits immediate clinical utility; leaves open IGFBP roles in colon cancer progression.
Purpose: The purpose of this study was to demonstrate the hypothesis that tussue IGFBP-2,-3, and-4 levels would differ between colon cancer tissue and adjacent normal tissue and to determine whether these factors could affect the clinicopathologic characteristics such as age, tumor stage, differentiation, serosal invasion, and CEA in patients with colon cancer. Methods: This study group consisted of 102 patients with colorectal cancer who under went operations between January 2004 and December 2006. Postoperative colon cancer specimens and adjacent normal colon tissues were obtained immediately. Histopathologic examinations were made by on pathologist for each specimen. The gene expressions of IGFBP-2,-3,-4 in cancer and normal tissues were measured using a reverse transcriptase-polymerase chain
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Kim et al. (2008) conducted an observational in colon cancer (n=102). Colon cancer tissue vs. Adjacent normal colon tissue was evaluated on Gene expressions of IGFBP-2, -3, -4.
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