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November 10, 2025Frontiers in NutritionOpen Access

Planetary Health Diet Index and self-reported kidney stones in US adults: mediating role of high-density lipoprotein cholesterol

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Authors

QYQingLong YangHCHaolin ChenNLNan Luo

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Overview

Observational data reveals higher Planetary Health Diet Index decreases kidney stones in adults, suggesting HDL may mediate this effect.

Key Points

  • The aim is to examine the relationship between the Planetary Health Diet Index and kidney stones, exploring the role of HDL cholesterol.
  • Analyzed data from 19,249 US adults from NHANES (2007-2018).
  • Assessed self-reported kidney stone diagnoses and PHDI scores.
  • Utilized multivariable logistic regression and mediation analyses.
  • Each 10-point increase in PHDI linked to an 8% reduced risk of kidney stones (OR, 0.92).
  • Top PHDI quintile had a 25% lower risk of kidney stones compared to the bottom quintile (OR, 0.75).
  • HDL-C mediated 6.0% of the relationship between PHDI and kidney stones.

Cite This Study

Yang et al. (2025) studied this question.

synapsesocial.com/papers/69253a24c0ce034ddc35720fhttps://doi.org/10.3389/fnut.2025.1609626
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Planetary Health Diet and Body Mass Distribution in Relation to Kidney Health: Evidence from NHANES 2003–20182025
  2. 2Planetary Health Diet Adherence and Medication Use in Older Adults with Chronic Kidney Disease: A Cross-Sectional Study2026
  3. 3A cross-sectional analysis of the relationship between the non-high density to high density lipoprotein cholesterol ratio (NHHR) and kidney stone risk in American adults2024 · 27 citations
  4. 4Association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and kidney stone: evidence from NHANES 2007–20182024 · 23 citations
  5. 5The association between non-high-density lipoprotein cholesterol to high-density lipoprotein cholesterol ratio (NHHR) and kidney stones: a cross-sectional study2024 · 35 citations