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November 10, 2025The Journal of Medical ResearchOpen Access

Profile of Infections in Sickle Cell Anemia (Disease or Trait): A Prospective Study from Western India

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Authors

APAbhinam PatelJLJ. D. LakhaniAMArti Muley

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Overview

Prospective study identifies infections and early mortality in adults with sickle cell anemia, suggesting urgent management interventions.

Key Points

  • To evaluate the spectrum of infections, associated complications, and outcomes in adult patients with sickle cell anemia.
  • Conducted as a prospective observational study in a tertiary care hospital in Gujarat, India
  • Enrolled 40 adults with confirmed sickle cell anemia (16 with SCD, 24 with SCT)
  • Systematically recorded clinical features, laboratory investigations, and microbiological culture results.
  • Fever was the most common symptom (95%)
  • Urinary tract infections were predominant (35%), mainly caused by Escherichia coli (45%)
  • Acute kidney injury occurred in 67.5% of cases, more common in SCT, with a mortality rate of 10%.

Cite This Study

Patel et al. (2025) studied this question.

synapsesocial.com/papers/69253a24c0ce034ddc357231https://doi.org/10.4103/jmr.jmr_65_25
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Clinical and Microbiological Profile of Infections in Hospitalized Patients with Sickle Cell Disease: A Tertiary Care Centre Experience from Central India2025
  2. 2Pattern of Reported Infections Among Paediatric Patients with Sickle Cell Disease: A Single-Centre Cohort Study in Nigeria2026
  3. 3Hospitalization Events Among Adolescents and Adults With Sickle Cell Disease in a Tertiary Care Center in Central India2024 · 2 citations
  4. 4Epidemiology and Clinical Impact of Sickle Cell Disease in India: Genetic Diversity, Regional Inequities, And Contemporary Management Approaches - A Review2026
  5. 5Sickle Cell Disorder: Unraveling the Diverse Clinical Presentations2024