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October 12, 2025CureusOpen Access

Clinical and Microbiological Profile of Infections in Hospitalized Patients with Sickle Cell Disease: A Tertiary Care Centre Experience from Central India

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Authors

AMAnjali MishraPKPankaj Kumar KannaujeVPVinay Pandit

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Overview

Observational study analyzes the clinical and microbiological profile of infections in sickle cell disease patients, highlighting significant infection predictors.

Key Points

  • Respiratory infections are most prevalent in hospitalized sickle cell disease patients, accounting for 34.6% of cases.
  • Elevated procalcitonin levels (>2 ng/mL) significantly correlate with adverse outcomes, indicating higher risks.
  • The SCD Infection Risk Score shows moderate ability to predict adverse events with an AUC of 0.78.
  • High antimicrobial resistance poses treatment challenges, underscoring the need for improved management strategies in this population.

Cite This Study

Mishra et al. (2025) studied this question.

synapsesocial.com/papers/68ec1be02b8fa9b2b78ad0cchttps://doi.org/10.7759/cureus.94286
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Profile of Infections in Sickle Cell Anemia (Disease or Trait): A Prospective Study from Western India2025
  2. 2Pattern of Reported Infections Among Paediatric Patients with Sickle Cell Disease: A Single-Centre Cohort Study in Nigeria2026
  3. 3Hospitalization Events Among Adolescents and Adults With Sickle Cell Disease in a Tertiary Care Center in Central India2024 · 2 citations
  4. 4Bacterial isolates in febrile children with sickle cell disease using molecular methods in sub-Saharan African – a single center study2026
  5. 5Anthropometric data from a large cohort of Indian sickle cell disease subjects.2025