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The aim is to identify organisms causing bacteraemia in febrile children with sickle cell disease using molecular methods.

Bacterial isolates in febrile children with sickle cell disease using molecular methods in sub-Saharan African – a single center study

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The aim is to identify organisms causing bacteraemia in febrile children with sickle cell disease using molecular methods.
Prospective cross-sectional study design
Participants aged 1-16 years, 112 recruited
Blood samples tested for bacteria using PCR and identified through NCBI BLAST search.
Bacteraemia prevalence was 75.6% using PCR.
Primary isolates included Streptococcus pneumoniae (30.1%), Haemophilus influenzae (28.0%), and Klebsiella pneumoniae (14.0%).
Findings indicate the need for strengthened infection prevention measures.

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Randomized trial identifies high prevalence of bacteraemia in children with sickle cell disease, suggesting urgent need for preventive measures.

Tolulope et al. (2026) studied this question.

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Randomized trial identifies high prevalence of bacteraemia in children with sickle cell disease, suggesting urgent need for preventive measures.