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November 6, 2025EP EuropaceOpen Access

Sarcopenia in Atrial Fibrillation: A Risk Factor for Adverse Outcomes in a UK Biobank Study

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Authors

HKHong Ju KimPYPil-Sung YangHPHanjin Park

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Overview

Retrospective cohort study finds sarcopenia increases risks of major bleeding and mortality in patients with atrial fibrillation, suggesting enhanced screening benefits.

Key Points

  • Evaluate the association between sarcopenia and adverse outcomes in atrial fibrillation patients using UK Biobank data.
  • Retrospective cohort study of individuals with atrial fibrillation enrolled in UK Biobank from 2006 to 2010.
  • Sarcopenia defined by EWGSOP2 criteria using handgrip and bioelectrical impedance analysis.
  • Propensity score weighting used to adjust for baseline differences.
  • 16.7% of patients with atrial fibrillation had sarcopenia.
  • Sarcopenia was associated with a composite outcome incidence of 43.9 per 1,000 person-years.
  • Adjusted hazard ratio for all-cause mortality in sercopenics was 1.44 (95% CI 1.24-1.68).
  • Major bleeding had an adjusted hazard ratio of 1.34 (95% CI 1.10-1.65).

Cite This Study

Kim et al. (2025) studied this question.

synapsesocial.com/papers/69253a39c0ce034ddc357e0chttps://doi.org/10.1093/europace/euaf286
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Association of sarcopenia with the long‐term risk of atrial fibrillation: A prospective cohort study2024 · 9 citations
  2. 2Effect of sarcopenia on risk of atrial fibrillation: a systematic review and meta-analysis of observational studies2026
  3. 3Association between sarcopenia and atrial fibrillation: a meta-analysis2026
  4. 4Sarcopenia in atrial fibrillation: a prospective study2026
  5. 5Osteosarcopenia as a Risk Factor for Atrial Fibrillation2026