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July 29, 2026Frontiers in MedicineOpen Access

Sarcopenia was associated with a significantly higher likelihood of developing atrial fibrillation compared to patients without sarcopenia (OR 2.16).

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Why the study?

Is sarcopenia associated with an increased risk of developing atrial fibrillation?

Population

3,067,241 patients across 6 studies

Comparison

Sarcopenia vs without sarcopenia

Design

Meta-analysis of observational studies

Key result

Sarcopenia was associated with a significantly higher likelihood of developing atrial fibrillation compared to patients without sarcopenia (OR 2.16).

Authors

PWPeng WangWSWentao ShiZYZhenze Yu

Discussion

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Overview

Sarcopenia may raise AF risk; leaves open need for prospective confirmation before clinical screening or intervention.

Study Design

Type

Meta-Analysis (n=3,067,241)

Structured PICO

Is sarcopenia associated with an increased risk of developing atrial fibrillation?

P
Population
3,067,241 adults from 6 observational studies comparing individuals with and without sarcopenia to evaluate the risk of developing atrial fibrillation.
E
Exposure
Sarcopenia (exposure)
C
Comparator
Patients without sarcopenia
O
Outcome
Development of atrial fibrillationhard clinical

Main Result

Odds Ratio: 2.16 (95% CI 1.8–2.6)

This meta-analysis demonstrates a significant association between sarcopenia and an increased risk of developing atrial fibrillation.

Limitations

  • All included studies were observational in design, which limits the ability to infer causality.
  • Substantial methodological heterogeneity across the included studies, including variability in the definitions and diagnostic criteria of sarcopenia.
  • Variations in the methods used to ascertain atrial fibrillation across studies.
  • Relatively small number of included studies limited the statistical power of subgroup analyses, meta-regression, and publication bias assessments.
  • Potential publication bias, as only published studies were included in the analysis.
  • observed heterogeneity
  • potential publication bias

Cite This Study

Wang et al. (2026) conducted a meta-analysis in Atrial fibrillation (n=3,067,241). Sarcopenia vs. Without sarcopenia was evaluated on Occurrence of atrial fibrillation (OR 2.16, 95% CI 1.80, 2.60). Sarcopenia was associated with a significantly higher likelihood of developing atrial fibrillation compared to patients without sarcopenia (OR 2.16).

synapsesocial.com/papers/6a7105a3e5469ee92be1a976https://doi.org/10.3389/fmed.2026.1853470
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