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Analysis of adherence thresholds for anticoagulants reveals significant outcomes in atrial fibrillation patients, suggesting updated definitions for nonadherence.
Optimal adherence thresholds are higher than conventionally assumed and, especially with DOACs, are strongly associated with clinical outcomes. These results provide a basis to consider updating the definition of OAC nonadherence to PDC <0.9 for DOACs and to PDC<0.9 or <0.95 for VKA, depending on the outcome.
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Safari et al. (2025) studied this question.
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