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November 1, 2025Journal of Medical Virology

Antigenic Imprinting and Immune Response Dynamics: Neutralization Against Emerging SARS‐CoV‐2 Omicron Variants Following Breakthrough Infections

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Authors

JLJianhua Li XWXingxing Wang JLJiaxuan Li

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Implication

Observational study reveals immune escape capabilities and limited booster effectiveness in breakthrough infections, suggesting revised vaccination strategies.

Key Points

To evaluate the immune response dynamics and neutralization against emerging SARS-CoV-2 Omicron variants after breakthrough infections.
Collected sera from 308 convalescent individuals with breakthrough infections and healthy individuals post-epidemic control.
Assessed serum susceptibility to various Omicron subvariants at multiple time points after infection.
Compared immune responses across different immunization regimens.
Two booster immunizations did not enhance the immune response against Omicron subvariants.
Breakthrough infections may weaken the immune response due to antigenic imprinting.
Findings highlight the need for optimized vaccination strategies.

Cite This Study

Li et al. (2025) studied this question.

synapsesocial.com/papers/6925436cc0ce034ddc3585f7 https://doi.org/10.1002/jmv.70681

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Implication

Observational study reveals immune escape capabilities and limited booster effectiveness in breakthrough infections, suggesting revised vaccination strategies.

Antigenic Imprinting and Immune Response Dynamics: Neutralization Against Emerging SARS‐CoV‐2 Omicron Variants Following Breakthrough Infections

Discussion

Member takes

Implication

Key Points

Cite This Study

Antigenic Imprinting and Immune Response Dynamics: Neutralization Against Emerging SARS‐CoV‐2 Omicron Variants Following Breakthrough Infections

Discussion

Member takes

Implication

Key Points

Cite This Study

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