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November 1, 2025Cancer MedicineOpen Access

Characteristics and Outcomes of Second Primary Multiple Myeloma in Adult Cancer Survivors: A Population‐Based Cohort Study

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Authors

LNLi NannanJZJiang-ping ZengZJZhixiang Jia

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Overview

Population-based cohort study shows distinct outcomes of second primary multiple myeloma in survivors, suggesting risk stratification is necessary for effective care.

Key Points

  • This study investigates the characteristics and outcomes of second primary multiple myeloma in adult cancer survivors, focusing on prior malignancy types.
  • Retrospective analysis of multiple myeloma patients using the SEER database from 2000 to 2021.
  • Stratification of patients with second primary multiple myeloma into subgroups based on prior primary malignancies.
  • Application of competing risk regression models and Cox regression model to analyze mortality risks.
  • Identified 74,932 patients with first primary myeloma and 6,465 with second primary myeloma.
  • Observed a higher proportion of males and older age at diagnosis in the 2-MM cohort.
  • Chemotherapy for prior lymphoma increased all-cause mortality risk, while radiotherapy for breast cancer reduced it.

Cite This Study

Nannan et al. (2025) studied this question.

synapsesocial.com/papers/69254f7dc0ce034ddc3590adhttps://doi.org/10.1002/cam4.71393
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Defining outcomes and risk of second primary malignancy (SPM) in patients with multiple myeloma (MM) in a large, integrated health system.2026
  2. 2Comparative Analysis of Primary and Second Primary Multiple Myeloma: A Propensity Score-Matched Study.2025
  3. 3Secondary multiple myeloma and antecedent cancer lineage.2026
  4. 4Investigating additional malignancies rates and overall survival of multiple myeloma patients: a SEER database study2024
  5. 5Second Primary Malignancy in Multiple Myeloma: a retrospective monocentric analysis of Department of Hematology of the Oncologic Hospital from Cagliari2025