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November 1, 2025The Journal of ImmunologyOpen Access

Mechanisms of iNOS-mediated protection against CNS damage in cryptococcal meningitis 3992

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Authors

JXJintao XuRHRylan HissongKGKristie Goughenour

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Overview

Experiment reveals iNOS mitigates CNS inflammation in cryptococcal meningitis, suggesting treatment pathways may improve outcomes.

Key Points

  • To explore the role of iNOS in CNS damage during cryptococcal meningitis and its influence on inflammation.
  • Utilized a murine model of cryptococcal meningitis
  • Assessed neurological symptoms and weight loss in iNOS-deficient mice
  • Investigated inflammation and brain damage through neutrophil and monocyte cell analysis
  • Examined IL-1α/IL-1β production in monocyte-derived cells
  • Correlated findings with human data on iNOS expression and outcomes
  • iNOS-deficient mice showed worsened neurological symptoms and rapid weight loss
  • Increased CNS inflammation and brain damage were observed in the absence of iNOS
  • Neutrophil depletion improved survival in iNOS-deficient mice
  • Higher levels of IL-1α/IL-1β production were noted with iNOS deficiency
  • Reduced iNOS expression in humans correlated with poorer neurological outcomes

Cite This Study

Xu et al. (2025) studied this question.

synapsesocial.com/papers/69254f8ec0ce034ddc3597f0https://doi.org/10.1093/jimmun/vkaf283.1728
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Central role of IL-10 in CNS-protection from Inflammatory Damage during Cryptococcus Meningoencephalitis 22539262026
  2. 2Delayed Reduction of Ischemic Brain Injury and Neurological Deficits in Mice Lacking the Inducible Nitric Oxide Synthase Gene1997 · 674 citations
  3. 3From Insight to Impact: Spotlight on the Potential Implications of the Neuronal Nitric Oxide Synthase Isoenzyme (nNOS) in Experimental Chronic Toxoplasmosis2026
  4. 4Organ-specific immune responses are strain-dependent in a mouse model of Cryptococcus neoformans brain infection2025
  5. 5Research progress on immunometabolism and gut microbiota in cryptococcal meningitis: mechanisms and therapeutic implications.2025 · 4 citations