Synapse
⌘+K
Synapse
PulseExploreClubsResearchersJournals
Instagram
HomeClubsExplore
October 23, 2025Journal of Tropical Pediatrics

Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial

View Full Paper
Ask AI
Bookmark
Share

Authors

RSRavendra SinghTBTapas BandyopadhyayAMArti Maria

Discussion

Loading...

Member takes

Overview

Randomized controlled trial shows NE improves outcomes in preterm neonates with septic shock, indicating potential treatment benefits.

Key Points

  • The study compares norepinephrine and dopamine for treating fluid-refractory septic shock in preterm neonates.
  • Double-blind randomized controlled trial conducted in a Level-III tertiary care hospital.
  • Fifty preterm neonates diagnosed with fluid-refractory septic shock were randomly assigned to receive either dopamine or norepinephrine.
  • Efficacy was measured by proportion of neonates achieving early reversal of shock within 45 minutes.
  • Dopamine group achieved early reversal in 42.3% of cases, compared to 62.5% in the NE group.
  • NE group required fewer additional vasoactive drugs—33.3% vs. 61.5% in dopamine group, P=.04.
  • Overall, NE showed comparable efficacy and safety for fluid-refractory septic shock treatment.

Cite This Study

Singh et al. (2025) studied this question.

synapsesocial.com/papers/69254f92c0ce034ddc359bd9https://doi.org/10.1093/tropej/fmaf045
View Full Paper
Ask AI
Bookmark
Share

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Norepinephrine Versus Dopamine as Initial Vasoactive Therapy in Neonatal Septic Shock: A Randomized Controlled Trial in a Tertiary Care Neonatal Intensive Care Unit in Eastern India2026
  2. 2The efficacy and safety of dopamine versus norepinephrine in management of paediatric septic shock2024 · 1 citations
  3. 3Role of Dopamine versus Adrenaline in Neonatal Septic Shock2026
  4. 4A pilot randomized controlled trial comparing noradrenaline and adrenaline as a first-line vasopressor for fluid-refractory septic shock in neonates2024 · 6 citations
  5. 5Early administration of norepinephrine in sepsis: Multicenter randomized clinical trial (EA-NE-S-TUN) study protocol2024 · 1 citations