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August 13, 2026Annals of African Medicine

Role of Dopamine versus Adrenaline in Neonatal Septic Shock

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Overview

Randomized trial compares the effects of dopamine versus adrenaline on neonatal septic shock outcomes, indicating potential benefits of adrenaline.

Key Points

  • This study aims to compare dopamine and adrenaline's efficacy and safety in managing neonatal septic shock.
  • Conducted a prospective, randomized, interventional trial in a Level III neonatal intensive care unit.
  • 150 neonates diagnosed with septic shock were randomly assigned to receive either dopamine or adrenaline.
  • Monitored outcomes included shock improvement, survival rates, and clinical parameters.
  • Shock improvement was observed in 60% of neonates treated with dopamine and 68% treated with adrenaline.
  • Mortality was 33.3% in the dopamine group compared to 20.0% in the adrenaline group.
  • Adrenaline showed statistically significantly better results in hemodynamic stability, urine output, and metabolic parameters.

Cite This Study

A 2026 study studied this question.

synapsesocial.com/papers/6a7d75c72b0e0cff3f63ea6ehttps://doi.org/10.4103/aam.aam_59_26
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Norepinephrine Versus Dopamine as Initial Vasoactive Therapy in Neonatal Septic Shock: A Randomized Controlled Trial in a Tertiary Care Neonatal Intensive Care Unit in Eastern India2026
  2. 2The efficacy and safety of dopamine versus norepinephrine in management of paediatric septic shock2024 · 1 citations
  3. 3Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial2025
  4. 4A pilot randomized controlled trial comparing noradrenaline and adrenaline as a first-line vasopressor for fluid-refractory septic shock in neonates2024 · 6 citations
  5. 5NORADRENALINE OR DOPAMINE IN SEPTIC SHOCK - A LITERATURE REVIEW2025