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August 9, 2026CureusOpen Access

Norepinephrine Versus Dopamine as Initial Vasoactive Therapy in Neonatal Septic Shock: A Randomized Controlled Trial in a Tertiary Care Neonatal Intensive Care Unit in Eastern India

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Authors

MPMoparthi PuramjaiDPDeepti Damayanty PradhanSPSantosh Kumar Panda

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Overview

Randomized trial compares norepinephrine and dopamine efficacy in neonatal septic shock, suggesting both are viable treatments.

Key Points

  • To compare the efficacy of norepinephrine and dopamine as initial vasopressors in neonatal septic shock.
  • Non-blinded parallel randomized controlled trial in a tertiary care neonatal intensive care unit.
  • Ninety neonates with septic shock randomized to norepinephrine (n=45) or dopamine (n=45).
  • Dopamine initiated at 10 mcg/kg/min and norepinephrine at 0.2 mcg/kg/min, with escalation based on clinical response.
  • Reversal of shock at 45 minutes: norepinephrine 31.1% vs. dopamine 35.5% (p=0.65).
  • Need for additional vasoactive support: norepinephrine 24.4% vs. dopamine 22.2% (p=0.80).
  • All-cause mortality: norepinephrine 15.5% vs. dopamine 13.3% (p=0.76).

Cite This Study

Puramjai et al. (2026) studied this question.

synapsesocial.com/papers/6a782d182e1896536c83feb2https://doi.org/10.7759/cureus.114127
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Dopamine versus norepinephrine in fluid-refractory septic shock among preterm neonates: a double-blind randomized controlled trial2025
  2. 2Role of Dopamine versus Adrenaline in Neonatal Septic Shock2026
  3. 3The efficacy and safety of dopamine versus norepinephrine in management of paediatric septic shock2024 · 1 citations
  4. 4Norepinephrine Versus Vasopressin as First-Line Vasopressor Therapy in Septic Shock: Implications for Patients Presenting to the Emergency Department2026
  5. 5Comparative Study of Using Norepinephrine Infusion versus Dopamine in Hemodynamically Unstable Patients at Surgical Intensive Care Unit2025