Neurobiological Effects of Combined Impact of Four-Factor Modeled Interplanetary Spaceflight in Relation to Typological Features of High Nervous Activity

For the first time, the neurobiological effects of the combined action of four key factors of interplanetary flight, simulated in a ground experiment – prolonged residence in hypomagnetic environment, synchronous exposure to prolonged gamma irradiation and simulated microgravity (antiorthostatic suspension) and irradiation of the head with 12C carbon ions – were investigated. It was discovered that hypomagnetic conditions aggravates the effects of the other three factors, which are discussed in our previous works, further increasing excitation. It was shown that the typological characteristics of the experimental animals make a certain contribution to these processes, which, in particular, can be seen in the metabolism of monoamines in key brain structures, especially in the dopaminergic system.