Answers are grounded in this paper and cite their sources.
Analysis reveals declining incidence ratios of ulcerative colitis to Crohn’s disease, indicating rising burden in inflammatory bowel disease and demanding higher healthcare resources.
Introduction: The ulcerative colitis (UC) to Crohn’s disease (CD) incidence ratio varies across geography and time. Methods: We analyzed UC:CD incidence ratios across three epidemiologic stages using generalized additive models for location, shape, and scale and pooled average annual percent changes (AAPCs) by meta-analysis. Results: Ratios significantly decreased: median 3.62 in stage 1, 1.82 in stage 2, 1.55 in stage 3; the incidence ratio stabilized in stage 3 (AAPC: −0.12; 95%CI: −0.66, 0.42). Discussion: Decreasing UC:CD incidence ratios signal a rising burden of CD, underscoring the need to anticipate greater healthcare demand, including higher treatment costs and higher prevalence of complications.
No takes yet. Share an insight, caveat, or question.
Windsor et al. (2025) studied this question.
Synapse has enriched 10 related papers. Consider them for comparative context: