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November 28, 2025PLoS neglected tropical diseasesOpen Access

Combination therapy with 3-Hydroxybenzaldehyde and Albendazole modulates mitochondrial protein expression in astrocytes after Angiostrongylus cantonensis infection

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Authors

YHYi-Hao HuangSCShih Hsin ChangCCChien-Ju Cheng

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Overview

Combination therapy demonstrates reduced mitochondrial protein expression in astrocytes with eosinophilic meningitis, indicating potential for treating neurological damage.

Key Points

  • Combined treatment reduced mitochondrial dysfunction and expression of cytochrome c and VDAC1 in astrocytes following infection.
  • Infection significantly elevated glial fibrillary acidic protein in five brain regions, indicating severe injury.
  • Analysis confirmed that 3-HBA suppressed mitochondrial-related effects in cultured mouse astrocytes activated by larval antigens.
  • Findings support using 3-HBA with albendazole for treating angiostrongyliasis; further study on mechanisms is needed.

Cite This Study

Huang et al. (2025) studied this question.

synapsesocial.com/papers/6928f106a65b730b9ea79c4ehttps://doi.org/10.1371/journal.pntd.0013773
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Combination therapy with 3-Hydroxybenzaldehyde and Albendazole modulates mitochondrial protein expression in astrocytes after Angiostrongylus cantonensis infection2025
  2. 2Doxycycline cotherapy with albendazole relieves neural function damage in C57BL/6 and BALB/c mice infected with Angiostrongylus cantonensis2024 · 3 citations
  3. 3Albendazole–doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis2026
  4. 4Targeting the RAGE/miR-185-3p axis enhances anthelmintic therapy and attenuates Angiostrongylus cantonensis–induced neuroinflammation2026
  5. 5Successful Management of Angiostrongylus Cantonensis‐Induced Eosinophilic Meningitis Using Albendazole–Corticosteroid Therapy: A Case Report With Serial Cytokine and CSF Monitoring2025