What question did this study set out to answer?

The research investigates whether albendazole–doxycycline co-therapy can provide neuroprotective benefits in mice infected with Angiostrongylus cantonensis.

February 9, 2026Parasites & VectorsOpen Access

Albendazole–doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis

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Authors

KJKai-Yuan JhanChang Gung University ESEny SofiyatunChang Gung University SCShao-Chieh ChiuChang Gung Memorial Hospital

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Implication

Demonstrates that albendazole–doxycycline therapy alleviates neuroinflammation in mouse neuroangiostrongyliasis, suggesting a potential treatment option.

Key Points

The research investigates whether albendazole–doxycycline co-therapy can provide neuroprotective benefits in mice infected with Angiostrongylus cantonensis.
Infected mice with third-stage larvae of A. cantonensis and assessed various treatment regimens.
Conducted histopathological analyses, western blotting, and ELISA to evaluate inflammation and marker levels.
Used magnetic resonance imaging (MRI) to track changes in brain structure and function.
Statistical analyses were performed using t-tests to compare outcomes between treatment groups.
ABZ-containing regimens significantly reduced worm recovery rates to near-zero levels.
Histopathology revealed reduced inflammation and damage in the brains of treated mice, particularly with co-therapy.
MRI showed less hyperintensity and edema in treated mice compared to untreated controls.
Co-therapy restored GFAP and IL-33 levels toward those of uninfected mice across different brain regions.

Cite This Study

Jhan et al. (2026) studied this question.

synapsesocial.com/papers/698979a6f0ec2af6756e7726 https://doi.org/10.1186/s13071-026-07284-6

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Implication

Demonstrates that albendazole–doxycycline therapy alleviates neuroinflammation in mouse neuroangiostrongyliasis, suggesting a potential treatment option.

Albendazole–doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis

Discussion

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Implication

Key Points

Cite This Study

Albendazole–doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis

Discussion

Member takes

Implication

Key Points

Cite This Study

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