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September 17, 2026Parasites & VectorsOpen Access

Targeting the RAGE/miR-185-3p axis enhances anthelmintic therapy and attenuates Angiostrongylus cantonensis–induced neuroinflammation

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Authors

CCChii-Wen ChouTungs' Taichung MetroHarbor HospitalCLChang-Sheng LinChang Bing Show Chwan Memorial HospitalCTChen‐Yuan TsengNational Chung Hsing University

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Overview

Preclinical study demonstrates that targeting RAGE or miR-185-3p improves anthelmintic efficacy in infected mice, indicating combination therapy mitigates parasite-induced brain injury.

Key Points

  • To investigate the regulatory roles of RAGE and miR-185-3p in Angiostrongylus cantonensis-induced neuroinflammation and determine whether targeting this axis improves anthelmintic treatment outcomes.
  • Infected mouse models of A. cantonensis were treated with albendazole, the RAGE antagonist Azeliragon, a miR-185-3p mimic, or combination regimens.
  • Evaluated larval recovery, blood-brain barrier permeability, histology, and expression of inflammatory markers and oxidative stress using Western blotting, ELISA, and qRT-PCR.
  • A. cantonensis infection significantly elevated RAGE, blood-brain barrier permeability, reactive oxygen species, and inflammatory mediators (TNF-α, IL-1β, IL-17A, COX-2, NF-κB), while downregulating miR-185-3p.
  • Treatment with Azeliragon or miR-185-3p mimic reversed infection-induced inflammatory changes and substantially improved blood-brain barrier integrity.
  • Co-treatment of albendazole with Azeliragon or miR-185-3p mimic led to the greatest reductions in larval recovery, blood-brain barrier permeability, and neuroinflammatory mediators.

Cite This Study

Chou et al. (2026) studied this question.

synapsesocial.com/papers/6aabb7865f706d05830e69d5https://doi.org/10.1186/s13071-026-07632-6
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Albendazole–doxycycline combination therapy alleviates MRI- and pathology-evident neuroinflammation and restores IL-33/GFAP balance in mouse neuroangiostrongyliasis2026
  2. 2Doxycycline cotherapy with albendazole relieves neural function damage in C57BL/6 and BALB/c mice infected with Angiostrongylus cantonensis2024 · 3 citations
  3. 3Dynamic alterations and potential roles of gut microbiota and metabolites in Angiostrongylus cantonensis-infected mice and rats2026
  4. 4Activation of the COX-2/mPGES-1/PGE-2 cascade through the NLRP3 inflammasome contributes to Angiostrongylus cantonensis-induced eosinophilic meningoencephalitis2024
  5. 5Combination therapy with 3-Hydroxybenzaldehyde and Albendazole modulates mitochondrial protein expression in astrocytes after Angiostrongylus cantonensis infection2025