Analysis reveals contractile injection system function in Streptomyces, indicating interactions with membrane protein and effector proteins.
Key Points
Cell death is induced by bacterial contractile injection systems in multicellular bacteria, highlighting their role in the Streptomyces life cycle.
CisA is identified as a membrane protein crucial to contractile injection system function, shown through cryo-electron tomography imaging.
Insights from single-particle cryo-electron microscopy provided an atomic model of the extended contractile injection system apparatus in Streptomyces.
CIS function differs from type VI secretion systems, suggesting unique evolutionary adaptation linked to regulated cell death.