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April 18, 2026Nature CommunicationsOpen Access

Structure of a contractile injection system in Salmonella enterica subsp. salamae

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Authors

RERooshanie N. EjazKFKristin FunkeCKClaudia S. Kielkopf

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Overview

High-resolution cryo-electron microscopy reveals contractile injection systems in Salmonella enterica, suggesting new engineering potentials.

Key Points

  • This research aims to uncover the structure and potential applications of contractile injection systems in Salmonella enterica subspecies salamae.
  • High-resolution cryo-electron microscopy was employed to determine the structure of the contractile injection system.
  • Genomic analyses were utilized to identify gene clusters associated with contractile injection systems in Salmonella enterica.
  • Functional assays were performed to assess the toxicity of the putative effector encoded within the operon.
  • The structure reveals a sheath architecture and a cage-like shell with a central spike.
  • A membrane-associated architecture was identified, differing from canonical eCISs, including interaction with the inner membrane.
  • Evidence of a putative effector with mild periplasmic toxicity has been presented, suggesting broader functionality for the eCIS.

Cite This Study

Ejaz et al. (2026) studied this question.

synapsesocial.com/papers/69e3213840886becb654062chttps://doi.org/10.1038/s41467-026-71989-6
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