What question did this study set out to answer?

The aim is to provide insights into the diversity and functional adaptations of receptor-binding domains in extracellular contractile injection systems.

January 24, 2026Nature CommunicationsOpen Access

A comprehensive catalogue of receptor-binding domains in extracellular contractile injection systems

View Full Paper

Ask AI

Bookmark

Authors

NNNimrod Nachmias ZWZhiren Wang XFXiao Feng

Discussion

Member takes

Overview

This comprehensive analysis reveals receptor binding diversity in extracellular contractile injection systems, highlighting new target cells.

Key Points

The aim is to provide insights into the diversity and functional adaptations of receptor-binding domains in extracellular contractile injection systems.
Performed a comprehensive analysis of eCIS tail fiber genes in bacterial and archaeal genomes.
Identified and categorized 3445 eCIS tail fiber proteins from 2585 loci across 1069 microbes.
Used structural prediction to classify tail fibers into 276 structural clusters and 1177 domain fold families.
Conducted experimental binding assays with a candidate tail fiber from Paenibacillus against THP-1 cells.
Discovered five new N-terminal domains responsible for tail fiber attachment.
Identified potential eCIS target cells and their diverse receptor binding capabilities.
Demonstrated that a specific tail fiber can bind D-mannose on human monocyte-like cells.

Cite This Study

Nachmias et al. (2026) studied this question.

synapsesocial.com/papers/6974616cbb9d90c67120b3c3 https://doi.org/10.1038/s41467-026-68710-y

View Full Paper

Ask AI

Bookmark

January 24, 2026Nature CommunicationsOpen Access

A comprehensive catalogue of receptor-binding domains in extracellular contractile injection systems

View Full Paper

Ask AI

Bookmark

Authors

NNNimrod Nachmias ZWZhiren Wang XFXiao Feng

Discussion

Member takes

Overview

This comprehensive analysis reveals receptor binding diversity in extracellular contractile injection systems, highlighting new target cells.

Key Points

The aim is to provide insights into the diversity and functional adaptations of receptor-binding domains in extracellular contractile injection systems.
Performed a comprehensive analysis of eCIS tail fiber genes in bacterial and archaeal genomes.
Identified and categorized 3445 eCIS tail fiber proteins from 2585 loci across 1069 microbes.
Used structural prediction to classify tail fibers into 276 structural clusters and 1177 domain fold families.
Conducted experimental binding assays with a candidate tail fiber from Paenibacillus against THP-1 cells.
Discovered five new N-terminal domains responsible for tail fiber attachment.
Identified potential eCIS target cells and their diverse receptor binding capabilities.
Demonstrated that a specific tail fiber can bind D-mannose on human monocyte-like cells.

Cite This Study

Nachmias et al. (2026) studied this question.

synapsesocial.com/papers/6974616cbb9d90c67120b3c3 https://doi.org/10.1038/s41467-026-68710-y

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

View Full Paper

Ask AI

Bookmark