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November 28, 2025Laboratory Service

Pediatric B-lineage acute lymphoblastic leukemia with CRLF2 rearrangements. Own experience in molecular genetic diagnostics and patient monitoring

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Authors

IKI. S. KotovGTG A TsaurECE.A. Chetverikova

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Overview

Analysis reveals genetic heterogeneity and minimal residual disease impact in pediatric B-lineage ALL with CRLF2 rearrangements.

Key Points

  • Event-free survival in patients with CRLF2 rearrangements is 0.49, indicating significant concerns with outcomes.
  • Minimal residual disease persistence does not significantly affect prognosis in pediatric B-lineage ALL patients.
  • Next-generation sequencing and multiplex ligase-dependent probe amplification were utilized for genetic analysis.
  • Identification of IKZF1plus profile associated with unfavorable outcomes highlights the need for careful monitoring.

Cite This Study

Kotov et al. (2025) studied this question.

synapsesocial.com/papers/6928f11ba65b730b9ea7a06dhttps://doi.org/10.17116/labs20251403114
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pediatric B-lineage acute lymphoblastic leukemia with CRLF2 rearrangements. Own experience in molecular genetic diagnostics and patient monitoring2025
  2. 2Genetic characteristics and treatment outcomes of pediatric acute lymphoblastic leukemia patients with CRLF2 rearrangements2025
  3. 3Outcomes of concomitant Philadelphia chromosome-positive and CRLF2-rearranged B-cell ALL2025
  4. 4Correlation between CRLF2 expression by flow cytometry and FISH in patients diagnosed with B-cell acute lymphoblastic leukemia2025
  5. 5Combination of p-STAT5, CRLF2 and copy number alterations as a potential indicator of a high-risk subgroup of acute lymphoblastic leukemia2026