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December 8, 2025BloodOpen Access

Genetic characteristics and treatment outcomes of pediatric acute lymphoblastic leukemia patients with CRLF2 rearrangements

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Authors

ECE. P. ChetverikovaRegional Children's Clinical Hospital No. 1ZPZh. V. PermikinUral State Medical UniversityTVTatyana VerzhbitskayaInstitute of Medical Cell Technologies

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Overview

Analysis reveals that pediatric acute lymphoblastic leukemia with CRLF2 rearrangements has varied treatment outcomes, suggesting the role of next-generation sequencing and hematopoietic stem cell.

Key Points

  • To characterize genetic and treatment outcomes in pediatric patients with acute lymphoblastic leukemia carrying CRLF2 rearrangements.
  • Included 958 pediatric patients with B-lineage acute lymphoblastic leukemia from a national trial.
  • Used flow cytometry and FISH for initial screening of CRLF2 rearrangement.
  • Subsequent genetic analysis performed via next-generation sequencing and multiplex ligation-dependent probe amplification.
  • CRLF2 rearrangements detected in 6.1% of patients, with high predictive accuracy of flow cytometry.
  • Event-free survival at 49% and overall survival at 81% in the cohort.
  • Hematopoietic stem cell transplantation was performed in 15.5% of patients, with varying survival outcomes.

Cite This Study

Chetverikova et al. (2025) studied this question.

synapsesocial.com/papers/693624dd4fa91c937236d1efhttps://doi.org/10.1182/blood-2025-6883
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Pediatric B-lineage acute lymphoblastic leukemia with CRLF2 rearrangements. Own experience in molecular genetic diagnostics and patient monitoring2025
  2. 2Pediatric B-lineage acute lymphoblastic leukemia with CRLF2 rearrangements. Own experience in molecular genetic diagnostics and patient monitoring2025
  3. 3Outcomes of concomitant Philadelphia chromosome-positive and CRLF2-rearranged B-cell ALL2025
  4. 4Correlation between CRLF2 expression by flow cytometry and FISH in patients diagnosed with B-cell acute lymphoblastic leukemia2025
  5. 5Combination of p-STAT5, CRLF2 and copy number alterations as a potential indicator of a high-risk subgroup of acute lymphoblastic leukemia2026