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November 28, 2025Nature CommunicationsOpen Access

Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma

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Authors

LCLaura Lucia CogrossiAPAnna PolicastroPZPaola Zordan

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Overview

Results indicate microbiome changes may improve immune checkpoint blockade therapy in myeloma, suggesting gut microbiota's role in regulating Th17 lymphocytes and plasma cell dyscrasias.

Key Points

  • Th17 lymphocyte expansion was suppressed significantly by Prevotella melaninogenica in treated mice, impacting disease progression.
  • Short-chain fatty acids were shown to reduce IL-17-mediated skin lesions linked to immune checkpoint blockade toxicity in trials.
  • Transgenic Vk*MYC mice were utilized to model the impact of microbiome modulation on myeloma progression and immune response.
  • Findings imply that gut microbiota manipulation may enhance treatment strategies for plasma cell dyscrasias and other related conditions.

Cite This Study

Cogrossi et al. (2025) studied this question.

synapsesocial.com/papers/6928f12ea65b730b9ea7a696https://doi.org/10.1038/s41467-025-65312-y
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  1. 1Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma2025 · 5 citations
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