November 24, 2025Nature CommunicationsOpen Access

Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma

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Authors

LCLaura Lucia CogrossiVita-Salute San Raffaele University PZPaola ZordanUniversità Cattolica del Sacro Cuore MGMatteo GrioniIRCCS Ospedale San Raffaele

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Implication

Transgenic mouse study reveals Prevotella melaninogenica enhances checkpoint efficacy and curbs toxicity in multiple myeloma, suggesting microbial modulation could improve plasma cell therapy.

Key Points

Prevotella melaninogenica delays progression to multiple myeloma and enhances anti-PD-L1 efficacy, while concurrently reducing adverse inflammatory skin toxicities.
Assessment in transgenic mice shows short-chain fatty acids from bacterial colonization suppress dendritic cells and prevent pro-inflammatory Th17 cells from expanding.
Supports microbiome modulation and metabolite supplementation to improve immune checkpoint blockade; Vk*MYC mouse model findings warrant validation in human trials.

Cite This Study

Cogrossi et al. (2025) studied this question.

synapsesocial.com/papers/69403b952d562116f290c746 https://doi.org/10.1038/s41467-025-65312-y

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Implication

Transgenic mouse study reveals Prevotella melaninogenica enhances checkpoint efficacy and curbs toxicity in multiple myeloma, suggesting microbial modulation could improve plasma cell therapy.

Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

Microbiome modulation uncouples efficacy and toxicity induced by immune checkpoint blockade in mouse multiple myeloma

Discussion

Member takes

Implication

Key Points

Cite This Study

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